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KMID : 0374019780010010001
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Ewha Medical Journal
1978 Volume.1 No. 1 p.1 ~ p.8
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Histochemical Observations on the Mucin of Epithelial Cells in Pathological Human Gallbladders
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Abstract
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The present study;. was performed to evaluate the histochemical properties of epithelial mucins in.diseased gallbladders.
18gallbladder specimens were selected in which metaplastic goblet cells had been observed. Of the specimens 9 were gallstone and 9 cholecystitis.
For microscopic examination, tissues were sectioned at a thickness 5pm, and were stained ivith following histochemical techniques: Alcian blue at pH 1.0 or 2.5111 and periodic acid Schiff´s reaction (PAS).
Observed results were as . follows:
1) In ordinary gallbladder the epithelial cells showed a predominance of sulphated mucosubstance.
2) In many case of cholelithiasis a typical goblet-typed epithelial cells were found in the top of folds. In large goblet cell area the relative ´proportion of sulphated acid mucin decreased and corresponding 13- non-sulphated acid mucin increased.
3) In the case of cholecystitis the intracellular mucin of high columnar epithelium predominated in the deep area of folds.
4) The neutral mucin predominated in under pathological condition.
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KEYWORD
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